ABSTRACT
Introduction: there is a substantial variation in COVID-19 case fatality rates across different locations, which may be due to differences in population age structure, patient factors, or health system factors. The study evaluated the clinical features and risk of COVID-19 morbidity and mortality among confirmed cases at COVID-19 referral treatment centre. Methods: the study was a retrospective analysis of routine data of cases admitted and treated between March 2020 to March 2021 at Greater Accra Regional Hospital (Ridge Hospital). The data were analysed using descriptive statistics, simple and multiple logistic regression. Results: the overall mortality rate among this cohort of patients was 34.4%. Compared to survivors, non-survivors were older patients, non-insured, had a higher frequency of hypertension, diabetes, heart disease, and were more prone to suffer from a severe form of COVID-19 infection. Compared to survivors, non-survivors showed elevated levels of white blood cell count, platelets, higher heartbeat per minute and lower levels of haemoglobin, creatinine, and oxygen saturation. The independent risk factors for COVID-19 mortality in the national treatment centre were shorter stay of hospitalizations, having a heart disease, difficulty in breathing, increased in concentration of platelets, and creatinine. A 1% increase in oxygen saturation decreased a patient's likelihood of dying from COVID-19 by 29.0%. Conclusion: this study showed COVID-19 mortality was associated with a shorter stay in hospital, having heart disease, dyspnoea, elevated levels of platelets and creatinine, and decreased oxygen saturation. There is a need for awareness creation about these risk factors to clinicians and public health officials.